Skin lesion analysis toward melanoma detection: A challenge at the 2017 International symposium on biomedical imaging (ISBI), hosted by the international skin imaging collaboration (ISIC)
David A. GutmanNoel CodellaM. E. CelebiBrian HelbaMichael A. MarchettiNabin K. MishraAllan C. Halpern
Establishes a standardized comparative benchmark for automated melanoma diagnosis by analyzing participant algorithms and results across lesion segmentation, dermoscopic feature detection, and disease classification on the ISIC 2017 dataset.
Skin cancer is the most common cancer in the United States, with melanoma responsible for over 9,000 deaths annually. Visual diagnosis by experts remains limited in accuracy, and shortages of dermatologists have increased interest in automated tools. The article describes the 2017 ISIC-hosted challenge that provided a large public dataset to benchmark algorithms for automated melanoma detection.
The challenge set out to evaluate methods across three tasks using a fixed snapshot of dermoscopic images: lesion segmentation, detection of four specific dermoscopic features, and classification into melanoma, seborrheic keratosis, or benign nevi. Training, validation, and test sets comprised 2,000, 150, and 600 images respectively. Submissions were evaluated with standard metrics including Jaccard index for segmentation and AUC for classification.
The effort attracted 593 registrations and 46 finalized submissions, making it the largest comparative study in the field. Top segmentation entries reached an average Jaccard index of 0.765 using deep learning ensembles, though 15–26% of images showed performance below inter-observer agreement. Feature detection achieved average AUC near 0.9 despite low participation. Classification yielded AUC values around 0.87–0.96, with ensembles of deep networks plus extra training data performing best; simple fusions of all submissions further improved results to an average AUC of 0.926.
These outcomes indicate that collaborative deep learning approaches can approach or exceed dermatologist-level sensitivity at useful specificity thresholds, supporting scalable automated triage. However, dataset bias across diseases, ages, devices, and ethnicities, incomplete feature annotations, and reliance on single metrics limit generalizability. Future challenges should refine evaluation metrics, reformat tasks for broader participation, and emphasize interpretable outputs for clinical integration. Additional diverse data and pilot studies in real workflows are needed before widespread deployment.
- Paper: U-Net: Convolutional Networks for Biomedical Image Segmentation, Olaf Ronneberger et al. (2015). This paper establishes the U-Net architecture for biomedical image segmentation, which serves as a foundational paradigm for the lesion segmentation methodologies benchmarked in the ISIC challenge.
- Paper: Fully convolutional networks for semantic segmentation, Jonathan Long et al. (2015). This work introduces end-to-end fully convolutional networks for dense pixel-level prediction, providing the underlying semantic segmentation framework utilized in modern medical image analysis challenges.
- Paper: Very Deep Convolutional Networks for Large-Scale Image Recognition, Karen Simonyan et al. (2015). This foundational work demonstrates the power of deep convolutional networks for visual feature extraction, underpinning the deep transfer learning and classification backbones deployed by challenge participants.
- Paper: Convolutional Neural Networks for Medical Image Analysis: Full Training or Fine Tuning?, Nima Tajbakhsh et al. (2016). This study demonstrates that fine-tuning pre-trained convolutional neural networks outperforms training from scratch on medical imaging tasks, justifying the transfer learning strategies adopted across the benchmark challenge.
- Paper: ImageNet Classification with Deep Convolutional Neural Networks, Alex Krizhevsky et al. (2012). This landmark paper establishes large-scale deep convolutional networks for image classification, introducing key regularization and training techniques essential for the skin lesion classification models in the challenge.
- Paper: ImageNet Large Scale Visual Recognition Challenge, Olga Russakovsky et al. (2014). This paper establishes the standardized large-scale benchmark methodology for evaluating computer vision models that inspired structured diagnostic challenges like the ISIC skin lesion competitions.
- Paper: Dermatologist-level classification of skin cancer with deep neural networks, Andre Esteva et al. (2017). This seminal paper scales deep learning on clinical and dermoscopic images to demonstrate dermatologist-level classification across thousands of skin diseases, extending the clinical benchmark and validation efforts initiated by the ISIC challenge.
- Paper: A survey on deep learning in medical image analysis, Geert Litjens et al. (2017). This comprehensive survey contextualizes the deep learning methodologies demonstrated in the ISIC challenge across broader medical image segmentation and classification benchmarks.
- Paper: Gender Shades: Intersectional Accuracy Disparities in Commercial Gender Classification, Joy Buolamwini et al. (2018). This study directly investigates intersectional disparities and skin-type biases in automated image analysis, addressing key limitations regarding demographic dataset bias raised by the ISIC challenge results.
- Paper: Generalised Dice Overlap as a Deep Learning Loss Function for Highly Unbalanced Segmentations, C. Sudre et al. (2017). This paper proposes the Generalized Dice loss to address severe class imbalance in medical image segmentation, directly tackling the boundary delineation challenges documented in benchmark evaluations.
- Paper: Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation, Liang-Chieh Chen et al. (2018). This work introduces DeepLabv3+, advancing encoder-decoder segmentation with atrous convolutions to improve multi-scale feature capture and boundary precision beyond earlier challenge baselines.
- Paper: The Effectiveness of Data Augmentation in Image Classification using Deep Learning, Luis Perez et al. (2017). This paper investigates advanced data augmentation strategies to improve deep learning performance on small, curated datasets, addressing the data scarcity and generalization issues highlighted in the challenge.
