cross-attention layer

Multiple instance learning (MIL)-based framework has become the mainstream for processing the whole slide image (WSI) with giga-pixel size and hierarchical image context in digital pathology. However, these methods heavily depend on a substantial number of bag-level labels and solely learn from the original slides, which are easily affected by variations in data distribution. Recently, vision language model (VLM)-based methods introduced the language prior by pre-training on large-scale pathological image-text pairs. However, the previous text prompt lacks the consideration of pathological prior knowledge, therefore does not substantially boost the model’s performance. Moreover, the collection of such pairs and the pre-training process are very time-consuming and source-intensive. To solve the above problems, we propose a dual-scale vision-language multiple instance learning (ViLa-MIL) framework for whole slide image classification. Specifically, we propose a dual-scale visual descriptive text prompt based on the frozen large language model (LLM) to boost the performance of VLM effectively. To transfer the VLM to process WSI efficiently, for the image branch, we propose a prototype-guided patch decoder to aggregate the patch features progressively by grouping similar patches into the same prototype; for the text branch, we introduce a context-guided text decoder to enhance the text features by incorporating the multi-granular image contexts. Extensive studies on three multi-cancer and multi-center subtyping datasets demonstrate the superiority of ViLa-MIL.

Deep Text-to-Image Synthesis (TIS) models such as Stable Diffusion have recently gained significant popularity for creative text-to-image generation. However, for domain-specific scenarios, tuning-free Text-guided Image Editing (TIE) is of greater importance for application developers. This approach modifies objects or object properties in images by manipulating feature components in attention layers during the generation process. Nevertheless, little is known about the semantic meanings that these attention layers have learned and which parts of the attention maps contribute to the success of image editing. In this paper, we conduct an in-depth probing analysis and demonstrate that cross-attention maps in Stable Diffusion often contain object attribution information, which can result in editing failures. In contrast, self-attention maps play a crucial role in preserving the geometric and shape details of the source image during the transformation to the target image. Our analysis offers valuable insights into understanding cross and self-attention mechanisms in diffusion models. Furthermore, based on our findings, we propose a simplified, yet more stable and efficient, tuning-free procedure that modifies only the self-attention maps of specified attention layers during the denoising process. Experimental results show that our simplified method consistently surpasses the performance of popular approaches on multiple datasets.

Recent years have witnessed the strong power of large text-to-image diffusion models for the impressive generative capability to create high-fidelity images. However, it is very tricky to generate desired images using only text prompt as it often involves complex prompt engineering. An alternative to text prompt is image prompt, as the saying goes: "an image is worth a thousand words". Although existing methods of direct fine-tuning from pretrained models are effective, they require large computing resources and are not compatible with other base models, text prompt, and structural controls. In this paper, we present IP-Adapter, an effective and lightweight adapter to achieve image prompt capability for the pretrained text-to-image diffusion models. The key design of our IP-Adapter is decoupled cross-attention mechanism that separates cross-attention layers for text features and image features. Despite the simplicity of our method, an IP-Adapter with only 22M parameters can achieve comparable or even better performance to a fully fine-tuned image prompt model. As we freeze the pretrained diffusion model, the proposed IP-Adapter can be generalized not only to other custom models fine-tuned from the same base model, but also to controllable generation using existing controllable tools. With the benefit of the decoupled cross-attention strategy, the image prompt can also work well with the text prompt to achieve multimodal image generation. The project page is available at \url{this https URL}.