query expansion

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues, it also has its own set of challenges: (1) LLMs are vulnerable to irrelevant or unhelpful context, (2) medical queries are often not well-targeted for helpful information, and (3) retrievers are prone to bias toward the specific source corpus they were trained on. In this study, we present RAG² (Rationale-Guided RAG), a new framework for enhancing the reliability of RAG in biomedical contexts. RAG² incorporates three key innovations: a small filtering model trained on perplexity-based labels of rationales, which selectively augments informative snippets of documents while filtering out distractors; LLM-generated rationales as queries to improve the utility of retrieved snippets; a structure designed to retrieve snippets evenly from a comprehensive set of four biomedical corpora, effectively mitigating retriever bias. Our experiments demonstrate that RAG² improves the state-of-the-art LLMs of varying sizes, with improvements of up to 6.1%, and it outperforms the previous best medical RAG model by up to 5.6% across three medical question-answering benchmarks. Our code is available at https://github.com/dmis-lab/RAG2

Automatic query expansion has long been suggested as a technique for dealing with the fundamental issue of word mismatch in information retrieval. A number of approaches to expansion have been studied and, more recently, attention has focused on techniques that analyze the corpus to discover word relationships (global techniques) and those that analyze documents retrieved by the initial query ( local feedback). In this paper, we compare the effectiveness of these approaches and show that, although global analysis has some advantages, local analysis is generally more effective. We also show that using global analysis techniques, such as word context and phrase structure, on the local set of documents produces results that are both more effective and more predictable than simple local feedback.

This paper proposes evaluation methods based on the use of non-dichotomous relevance judgements in IR experiments. It is argued that evaluation methods should credit IR methods for their ability to retrieve highly relevant documents. This is desirable from the user point of view in modern large IR enviroments. The proposed methods are (1) a novel application of P-R curves and average precision computations based on separate recall bases for documents of different degrees of relevance, and (2) two novel measures computing the cumulative gain the user obtains by examining the retrieval result up to a given ranked position. We then demonstrate the use of these evaluation methods in a case study on the effectiveness of query types, based on combinations of query structures and expansion, in retrieving documents of various degrees of relevance. The test was run with a best match retrieval system (InQuery¹) in a text database consisting of newspaper articles. The results indicate that the tested strong query structures are most effective in retrieving highly relevant documents. The differences between the query types are practically essential and statistically significant. More generally, the novel evaluation methods and the case demonstrate that non-dichotomous relevance assessments are applicable in IR experiments, may reveal interesting phenomena, and allow harder testing of IR methods.